| 描述 |
Hyaluronic acid (HA) is extensively utilized in aesthetic medicine for its capacity to bind a significant number of water molecules, enhancing tissue hydration and mechanical resistance. HA is pivotal in processes such as wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It is also explored in clinical research for its potential roles in tumor markers, liver diseases, and pharmaceutical applications[1]. In the realm of oncology, hyaluronan significantly influences cancer progression and metastasis. The interaction between HA and HA fragments with tumor cells triggers downstream signaling pathways, which enhance cell proliferation, adhesion, migration, and invasion. This interaction also promotes angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, properties akin to stem cells, and resistance to chemotherapy and radiation, particularly in digestive cancers[2]. |
