Methyl Linolenate

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Chemical Structure| 301-00-8 同义名 : α-亚麻酸甲酯 ;Linolenic acid methyl ester; Methyl octadecatrienoate (all cis-9,12,15); Methyl alpha-linolenate; C18:3 (all cis-9,12,15) Methyl ester
CAS号 : 301-00-8
货号 : A1456329
分子式 : C19H32O2
纯度 : 80%
分子量 : 292.46
MDL号 : MFCD00135851
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(359.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 As a polyunsaturated fatty acid (PUFA), Methyl linolenate exhibits anti-melanogenesis properties, with an inhibition concentration (IC50) value of 60 μM. It is also useful in research focused on the mechanisms and prevention of oxidation/peroxidation in unsaturated fatty acids[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.42mL

0.68mL

0.34mL

17.10mL

3.42mL

1.71mL

34.19mL

6.84mL

3.42mL
参考文献

[1]Huh S et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull, 2010, 33(7):1242-5.

[2]Li X et al. Benchmark Calculations for Bond Dissociation Enthalpies of Unsaturated Methyl Esters and the Bond Dissociation Enthalpies of Methyl Linolenate. J Phys Chem A, 2016, Jun 16, 120(23):4025-36

[3]Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5.

[4]Ko GA, et al. Sageretia thea fruit extracts rich in methyl linoleate and methyl linolenate downregulate melanogenesis via the Akt/GSK3β signaling pathway. Nutr Res Pract. 2018 Feb;12(1):3-12.