Sacubitrilat

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Chemical Structure| 149709-44-4 同义名 : LBQ-657; Desethyl Sacubitril; Sac
CAS号 : 149709-44-4
货号 : A145106
分子式 : C22H25NO5
纯度 : 99%+
分子量 : 383.44
MDL号 : MFCD00921225
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(273.84 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Sacubitrilat (LBQ657) is characterized by its specific stereochemistry, making it a potent inhibitor (5 nM) of the neutral endopeptidase (NEP) through a comprehensive network of interactions at the enzyme's active site[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.08mL

5.22mL

2.61mL
参考文献

[1]Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.

[2]Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72(8):917-24.