Amifostine thiol

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Chemical Structure| 31098-42-7 同义名 : WR-1065
CAS号 : 31098-42-7
货号 : A1441585
分子式 : C5H14N2S
纯度 : 98%
分子量 : 134.24
MDL号 : MFCD00296912
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1862.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(744.92 mM)，配合低频超声助溶
生物活性
描述 Amifostine thiol (WR-1065), an active metabolite of the cytoprotector Amifostine, exhibits cytoprotective and radioprotective properties. It activates p53 through a JNK-dependent signaling pathway [1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.45mL

1.49mL

0.74mL

37.25mL

7.45mL

3.72mL

74.49mL

14.90mL

7.45mL
参考文献

[1]Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45(12): 1674-1681.

[2]Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87. J Biol Chem. 2003 Apr 4;278(14):11879-87.

[3]J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30(6): 283-294.