YM-1

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Chemical Structure| 409086-68-6 同义名 : -
CAS号 : 409086-68-6
货号 : A1399071
分子式 : C20H20ClN3OS2
纯度 : 99%+
分子量 : 417.98
MDL号 : MFCD28009511
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(71.77 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(119.62 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 YM-1, a stable, soluble analog of MKT-077, functions as an orally active inhibitor of Hsp70. It triggers cell death in HeLa cells and significantly increases the levels of p53 and p21 proteins, indicating its potential in modulating cell cycle and apoptosis pathways[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.96mL

2.39mL

1.20mL

23.92mL

4.78mL

2.39mL
参考文献

[1]Wang AM, et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol. 2013 Feb;9(2):112-8.

[2]Khondoker Md Zulfiker Rahman, et al. Effect of an Inhibitor of HSP70, YM-1, on Hikeshi Knockout Cells. Thermal Medicine. 2017, 33(4):129-134.