(E/Z)-GO289

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Chemical Structure| 694522-87-7 同义名 : -
CAS号 : 694522-87-7
货号 : A1398885
分子式 : C17H15BrN4O2S
纯度 : 99%+
分子量 : 419.3
MDL号 : MFCD03718152
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(38.16 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CK2

    CK2, IC50:7 nM
描述 (E/Z)-GO289 is a potent and selective CK2 inhibitor with an IC50 value of 7 nM that significantly prolongs the circadian cycle. (E/Z)-GO289 is able to manipulate clock protein phosphorylation , and has a cell type-dependent inhibitory effect on cancer cell growth. At a concentration of 3-9 μM for 2 days, (E/Z)-GO289 strongly inhibited the growth of Caki-2, A498 and 769-P cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.92mL

2.38mL

1.19mL

23.85mL

4.77mL

2.38mL
参考文献

[1]Oshima T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Sci Adv. 2019;5(1):eaau9060. Published 2019 Jan 23.