Esmolol HCl

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Chemical Structure| 81161-17-3 同义名 : Esmolol (hydrochloride); ASL8052; esmolol; 81161-17-3; Brevibloc; Esmolol hydrochloride
CAS号 : 81161-17-3
货号 : A139525
分子式 : C16H26ClNO4
纯度 : 95%
分子量 : 331.83
MDL号 : MFCD00941432
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(316.42 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(150.68 mM)
动物实验配方：
生物活性
靶点

  • β-adrenergic receptor
描述 Esmolol hydrochloride is a cardioselective b-blocker, used to control rapid heartbeats or abnormal heart rhythms.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02609152 Shock, Septic Phase 3 Withdrawn(logistical difficult... 展开 >>ies) 收起 << August 2017 France ... 展开 >> APHM - Hôpital Nord Marseille Cedex 20, France, 13915 CHRU de Nîmes - Hôpital Universitaire Carémeau Nîmes Cedex 09, France, 30029 收起 <<
NCT02033629 Cardiac Surgery Phase 3 Recruiting October 2018 Saudi Arabia ... 展开 >> Dammam University Recruiting Khobar, Eastern, Saudi Arabia, 31952 Contact: Mohamed R El Tahan, MD    +966138651193    mohamedrefaateltahan@yahoo.com 收起 <<
NCT01688648 Unstable Angina ... 展开 >> Coronary Artery Bypass Graft Dexmedetomidine Lidocaine Myocardial Injury Arrhythmia Blood Electrolyte Balance 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.01mL

0.60mL

0.30mL

15.07mL

3.01mL

1.51mL

30.14mL

6.03mL

3.01mL
参考文献

[1]Suzuki T, Morisaki H, et al. Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med. 2005 Oct;33(10):2294-301.

[2]Wiest D. Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics. Clin Pharmacokinet. 1995 Mar;28(3):190-202.