Zabedosertib
产品说明书
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同义名 : | BAY 1834845 |
| CAS号 : | 1931994-81-8 | |
| 货号 : | A1388394 | |
| 分子式 : | C20H21F3N4O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 470.47 | |
| MDL号 : | MFCD32900903 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(255.07 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with an IC50 of 3.55 nM, showing immunomodulatory potential. IRAK4 is a kinase integral to signaling innate immune responses from Toll-like receptors [1]. Zabedosertib also exhibits anti-inflammatory properties against IL-β, LPS, and Imiquimod-induced inflammation [2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.63mL 2.13mL 1.06mL |
21.26mL 4.25mL 2.13mL |
| 参考文献 |
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