(E/Z)-IT-603

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Chemical Structure| 292168-90-2 同义名 : -
CAS号 : 292168-90-2
货号 : A1383553
分子式 : C11H9BrN2O3S
纯度 : 99%+
分子量 : 329.17
MDL号 : MFCD00242812
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(364.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603. (E/Z)-IT-603 is a c-Rel inhibitor with an IC50 value of 3 μM. (E/Z)-IT-603 has antitumour activity. In graft-versus-host disease (GVHD) and malignant diseases, (E/Z)-IT-603 has shown that it can be used as a promising modulator of T-cell responses[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.19mL

3.04mL

1.52mL

30.38mL

6.08mL

3.04mL
参考文献

[1]Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591.