Bractoppin

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Chemical Structure| 2290527-07-8 同义名 : -
CAS号 : 2290527-07-8
货号 : A1378671
分子式 : C25H23FN4O
纯度 : 99%
分子量 : 414.47
MDL号 : MFCD00868218
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(603.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the human BRCA1 tandem BRCT domain (IC50: 74 nM). It reduces BRCA1 recruitment to DNA breaks, thereby suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin predominantly inhibits BRCA1 tBRCT-dependent processes in the DNA damage response[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL
参考文献

[1]Jayaprakash Periasamy, et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12.