Fisogatinib

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Chemical Structure| 1707289-21-1 同义名 : BLU-554
CAS号 : 1707289-21-1
货号 : A137706
分子式 : C24H24Cl2N4O4
纯度 : 99%+
分子量 : 503.38
MDL号 : MFCD30496704
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(208.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • FGFR4

    FGFR4, IC50:5 nM
描述 Fisogatinib, also known as BLU-554, is a strong, highly selective, and orally bioavailable inhibitor of FGFR4, exhibiting IC50 value of 5 nM. It demonstrates considerable efficacy against tumors in hepatocellular carcinoma (HCC) models that rely on FGFR4 signaling[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.93mL

1.99mL

0.99mL

19.87mL

3.97mL

1.99mL
参考文献

[1]Dogan-Topal B, et al. Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 15;1110-1111:116-123.