Benzamil HCl

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Chemical Structure| 161804-20-2 同义名 : Benzylamiloride hydrochloride; Benzamil (hydrochloride); Benzamil HCl, Benzamil Hydrochloride; Benzamil hydrochloride
CAS号 : 161804-20-2
货号 : A1371164
分子式 : C13H15Cl2N7O
纯度 : 99%
分子量 : 356.21
MDL号 : MFCD00069219
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(294.77 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Benzamil hydrochloride (Benzylamiloride hydrochloride), a derivative of Amiloride, acts as an inhibitor of the Na+/Ca2+ exchanger (NCX) with an IC50 of approximately 100 nM. It also serves as a non-selective blocker of Deg/epithelial sodium channels (ENaC) and enhances myogenic vasoconstriction. Additionally, Benzamil hydrochloride blocks TRPP3-mediated Ca2+-activated currents, demonstrating an IC50 of 1.1 μM[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.04mL

2.81mL

1.40mL

28.07mL

5.61mL

2.81mL
参考文献

[1]Fischer KG, et al. Characterization of a Na(+)-Ca(2+) exchanger in podocytes. Nephrol Dial Transplant. 2002 Oct;17(10):1742-50.

[2]Wang X, et al. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008 Jul;295(1):F272-82.

[3]Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.

[4]Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738.

[5]Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.