MSA-2

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Chemical Structure| 129425-81-6 同义名 : 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid
CAS号 : 129425-81-6
货号 : A1365634
分子式 : C14H14O5S
纯度 : 98%
分子量 : 294.32
MDL号 : MFCD32640674
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(169.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MSA-2, a powerful orally available non-nucleotide STING agonist, binds to STING as a noncovalent dimer with nanomolar affinity. It displays EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. MSA-2 promotes interferon-β secretion in tumors, leads to tumor regression with lasting antitumor immunity, and enhances the effectiveness of anti-PD-1 therapy in syngeneic mouse tumor models[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.40mL

0.68mL

0.34mL

16.99mL

3.40mL

1.70mL

33.98mL

6.80mL

3.40mL
参考文献

[1]Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.

[2]Liu J, et al. Identification of MSA-2: An oral antitumor non-nucleotide STING agonist. Signal Transduct Target Ther. 2021;6(1):18. Published 2021 Jan 12.