NP-G2-044

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Chemical Structure| 1807454-59-6 同义名 : -
CAS号 : 1807454-59-6
货号 : A1365358
分子式 : C21H16F3N3O2
纯度 : 99%+
分子量 : 399.37
MDL号 : MFCD32708511
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NP-G2-044 is a highly potent, orally bioavailable inhibitor of fascin, with an IC50 of approximately 2 μM. It effectively impedes tumor metastasis and enhances the antitumor immune response [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.52mL

2.50mL

1.25mL

25.04mL

5.01mL

2.50mL
参考文献

[1]Han S, et al. Improving fascin inhibitors to block tumor cell migration and metastasis. Mol Oncol. 2016;10(7):966-980.

[2]Vincent Chung, et al. Abstract C053: NP-G2-044, a novel fascin inhibitor, blocks tumor metastasis and increases antitumor immune response.

[3]Fascin Inhibitor NP-G2-044.