VBIT 4

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Chemical Structure| 2086257-77-2 同义名 : -
CAS号 : 2086257-77-2
货号 : A1364932
分子式 : C21H23ClF3N3O3
纯度 : 99%+
分子量 : 457.87
MDL号 : MFCD32663268
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VBIT-4 inhibits the oligomerization of voltage-dependent anion channel 1 (VDAC1) with a binding affinity (Kd) of 17 μM. As an inhibitor of apoptosis, it has potential therapeutic applications in conditions associated with apoptosis, including neurodegenerative and cardiovascular diseases [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.92mL

2.18mL

1.09mL

21.84mL

4.37mL

2.18mL
参考文献

[1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.