Rheb inhibitor NR1

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Chemical Structure| 2216763-38-9 同义名 : -
CAS号 : 2216763-38-9
货号 : A1364808
分子式 : C25H19BrCl2N2O3S
纯度 : 99%
分子量 : 578.31
MDL号 : MFCD31714165
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(86.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Rheb inhibitor NR1 exhibits an IC50 of 2.1 µM in the Rheb-IVK assay. It directly binds Rheb in the switch II domain, selectively inhibiting the activation of mechanistic target of rapamycin complex 1 (mTORC1). NR1 inhibits T389pS6K1 phosphorylation by mTORC1 and enhances S473pAKT phosphorylation dose-dependently. It does not affect mTORC2 activity [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.73mL

0.35mL

0.17mL

8.65mL

1.73mL

0.86mL

17.29mL

3.46mL

1.73mL
参考文献

[1]Mahoney SJ, et al. A small molecule inhibitor of Rheb selectively targets mTORC1 signaling. Nat Commun. 2018 Feb 7;9(1):548.