JAK2-IN-6

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Chemical Structure| 353512-04-6 同义名 : -
CAS号 : 353512-04-6
货号 : A1364451
分子式 : C14H10ClN3OS2
纯度 : 98%
分子量 : 335.83
MDL号 : MFCD03234340
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(178.66 mM)，配合低频超声，并调节pH至5，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 JAK2-IN-6, a multiple-substituted aminothiazole derivative, is a potent and selective inhibitor of JAK2, exhibiting an IC50 of 22.86 μg/mL. JAK2-IN-6 does not exhibit activity against JAK1 and JAK3. It demonstrates an anti-proliferative effect against cancer cells [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.89mL

2.98mL

1.49mL

29.78mL

5.96mL

2.98mL
参考文献

[1]Ting-Ting Yao, et al. Integration of pharmacophore mapping and molecular docking in sequential virtual screening: towards the discovery of novel JAK2 inhibitors. RSC Adv., 2017, 7, 10353-10360.