MS48107

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Chemical Structure| 2375070-79-2 同义名 : -
CAS号 : 2375070-79-2
货号 : A1361844
分子式 : C23H20FN5O2
纯度 : 99%
分子量 : 417.44
MDL号 : N/A
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(251.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). It shows selectivity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can effectively cross the blood-brain barrier (BBB) in mice[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

11.98mL

2.40mL

1.20mL

23.96mL

4.79mL

2.40mL
参考文献

[1]Xufen Yu, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem. 2019 Aug 22;62(16):7557-7574.