iJak-381
产品说明书
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同义名 : | - |
| CAS号 : | 1831144-46-7 | |
| 货号 : | A1353321 | |
| 分子式 : | C28H28ClF2N9O3 | |
| 纯度 : | 97% | |
| 分子量 : | 612.03 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | iJak-381 acts as an inhibitor of JAK1/2, exhibiting anti-inflammatory properties. It disrupts IL-13 signaling and also impedes the signaling pathways of IL-4 and IL-6. Additionally, iJak-381 lowers p-STAT6 levels and curtails the entry of inflammatory cells into the mouse lungs. It effectively prevents airway hyperresponsiveness (AHR)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.63mL 0.33mL 0.16mL |
8.17mL 1.63mL 0.82mL |
16.34mL 3.27mL 1.63mL |
| 参考文献 |
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