Tubeimoside I
产品说明书
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同义名 : | 土贝母苷甲;土贝母苷甲I;土贝母苷I ;Tubeimoside-1; Lobatoside-H; Tubeimoside A |
| CAS号 : | 102040-03-9 | |
| 货号 : | A134125 | |
| 分子式 : | C63H98O29 | |
| 纯度 : | 99% | |
| 分子量 : | 1319.43 | |
| MDL号 : | MFCD28396382 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(79.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tubeimoside I is a naturally occuring triterpenoid saponin isolated from the medicinal herb B. paniculatum, with anti-inflammatory, apoptotic and antitumor activity. TBMS I inhibited the proliferation of both HepG2 and L-02 cells in a dose- and time-dependent manner, but HepG2 cells appeared more sensitive to the agent. When exposed to TBMS I for 24, 48 and 72 h, IC₅₀ for HepG2 cells versus L-02 cells were 15.5 vs. 23.1, 11.7 vs. 16.2, 9.2 vs. 13.1 (µM), respectively. TBMS I induced cell shrinkage, nuclear condensation and fragmentation, cell cycle arrest at the G2/M phase, mitochondrial membrane disruption, release of cytochrome c from the mitochondria, activation of caspase 3 and 9, and shifting Bax/Bcl-2 ratio from being anti-apoptotic to pro-apoptotic, all indicative of initiation and progression of apoptosis involving mitochondrial dysfunction[3]. TBMS1 significantly inhibited the production of the pro-inflammatory cytokines, TNF-α, IL-6 and IL-1β in vitro and in vivo. Pretreatment with TBMS1 markedly attenuated the development of pulmonary edema, histological severities and inflammatory cells infiltration in mice with ALI(Acute lung injury)[4]. Tubeimoside I attenuates osteoclastogenesis through down-regulating NF-κB signaling pathway, and is a potential candidate for the treatment of bone-destructive diseases like type 2 diabetic osteoporosis[5]. TBMS1 can effectively sensitize CDDP (Cisplatin) in CDDP-resistant human ovarian cancer cells through the down-regulation of the ERK1/2 and the up-regulation of the p38 signaling pathways[6]. TBMS1 might activate PTP1B(protein-tyrosine phosphatase 1B), which further hyperactivates MEK1/2-ERK1/2 cascade, thereby inhibiting cell proliferation in melanoma[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.76mL 0.15mL 0.08mL |
3.79mL 0.76mL 0.38mL |
7.58mL 1.52mL 0.76mL |
| 参考文献 |
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