GSK-3β inhibitor 2

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Chemical Structure| 1702428-31-6 同义名 : -
CAS号 : 1702428-31-6
货号 : A1329215
分子式 : C14H14N4O3S
纯度 : 99%+
分子量 : 318.35
MDL号 : MFCD32708518
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(12.56 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GSK-3β inhibitor 2, a potent, selective, and orally bioavailable inhibitor of GSK-3β, exhibits an IC50 of 1.1 nM. Capable of crossing the blood-brain barrier, it holds potential for treating Alzheimer's disease[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.71mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL
参考文献

[1]Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63.