CIL62

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Chemical Structure| 117593-36-9 同义名 : -
CAS号 : 117593-36-9
货号 : A1327310
分子式 : C23H26O5
纯度 : 98%
分子量 : 382.45
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(313.77 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Apoptosis s a well understood form of regulated cell death. The unique morphological and biochemical changes associated with apoptosis are due to the executioner caspase proteases. CIL62 is an inducer of caspase-3/7-independent cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death. CIL62 induced cell death that was suppressed by Necrostatin-1. 19 µM (5 µg/mL) Necrostatin-1 suppresseed CIL62, but CIL62 was not suppressed by the ferroptosis inducers (antioxidants or iron-chelators)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.07mL

2.61mL

1.31mL

26.15mL

5.23mL

2.61mL
参考文献

[1]Shimada K, Skouta R, Kaplan A, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016;12(7):497-503. doi:10.1038/nchembio.2079

[2]Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.