Lithospermic acid

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Chemical Structure| 28831-65-4 同义名 : Lithospermic Acid A; (+)-Lithospermic Acid
CAS号 : 28831-65-4
货号 : A132651
分子式 : C27H22O12
纯度 : 99%+
分子量 : 538.46
MDL号 : MFCD03427311
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(195 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 65 mg/mL(120.71 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Lithospermic acid is a natural product isolated and purified from the roots of Lithospermum ruderale with anti-HIV, anti-gonadotrophic and anti-thyroidal effects, and is a cardiotonic agent[3]. LSA (Lithospermic Acid) inhibited the formation of uric acid and superoxide radicals significantly with an IC50 5.2 and 1.08 mg/ml, respectively, and exhibited competitive inhibition. LSA scavenged superoxide radicals directly in the system beta-NADH/PMS and inhibited the production of superoxide in human neutrophils stimulated by PMA and fMLP. LSA also have hypouricemic activity on oxonate-pretreated rats in vivo and have anti-inflammatory effects in a model of gouty arthritis[4]. Lithospermic acid significantly attenuated the CCl4-induced oxidative damage in a concentration-dependent manner. Pretreatment of mice with lithospermic acid for six days significantly reduced CCl4-induced hepatic oxidative damage, serum AST (aspartate transaminase) and ALT(alanine transaminase). The pretreatment also increased SOD (superoxide dismutase) and CAT (catalase)[5]. Lithospermic acid possesses specific inhibitory effect on caspase 3[6]. Lithospermic acid attenuates mesenteric ischemia reperfusion injury in rat intestines by increasing tissue SOD and GPx (glutathione peroxidase) activities and decreasing MDA and MPO (myeloperoxidase) levels. Lithospermic acid also improves morphological alterations which occurred after periods of reperfusion[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.29mL

1.86mL

0.93mL

18.57mL

3.71mL

1.86mL
参考文献

[1]Lin YL, Tsay HJ, et al. Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways. J Biomed Sci. 2015 May 28;22:37.

[2]Xiuli W, Wei G, Mao S. Pharmacokinetic investigation on interaction between hydrophilic lithospermic acid B and lipophilic tanshinone IIA in rats: an experi-mental study. J Tradit Chin Med. 2015 Apr;35(2):206-10.

[3]Mori M, Ciaco S, Mély Y, Karioti A. Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein. Molecules. 2020 Nov 20;25(22):5434

[4]Liu X, Chen R, Shang Y, Jiao B, Huang C. Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats. Chem Biol Interact. 2008 Nov 25;176(2-3):137-42

[5]Chan KW, Ho WS. Anti-oxidative and hepatoprotective effects of lithospermic acid against carbon tetrachloride-induced liver oxidative damage in vitro and in vivo. Oncol Rep. 2015 Aug;34(2):673-80

[6]Lin YL, Tsay HJ, Lai TH, Tzeng TT, Shiao YJ. Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways. J Biomed Sci. 2015 May 28;22(1):37

[7]Ozturk H, Terzi EH, Ozgen U, Duran A, Ozturk H. Lithospermic acid and ischemia/reperfusion injury of the rat small intestine prevention. Adv Clin Exp Med. 2012 Jul-Aug;21(4):433-9