Fidaxomicin

产品说明书

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Chemical Structure| 873857-62-6 同义名 : 非达米星 ;OPT-80; PAR-101; Dificlir; Dificid; Tiacumicin B; Lipiarmycin; Difimicin; Clostomicin B1; Fidaxomycin
CAS号 : 873857-62-6
货号 : A132323
分子式 : C52H74Cl2O18
纯度 : 98%
分子量 : 1058.04
MDL号 : MFCD27976367
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(33.08 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Fidaxomicin (OPT-80), identified as a macrocyclic antibiotic, acts as a potent inhibitor of RNA polymerase when taken orally. It exhibits a narrow antibacterial spectrum, notably showing strong activity against Clostridium difficile (MIC90=0.12 μg/mL), making it valuable for research into Clostridium difficile infections (CDI)[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.95mL

0.19mL

0.09mL

4.73mL

0.95mL

0.47mL

9.45mL

1.89mL

0.95mL
参考文献

[1]Poxton IR, et al. Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections. Future Microbiol. 2010 Apr;5(4):539-48.

[2]Tannock GW, et al. A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin. Microbiology (Reading). 2010 Nov;156(Pt 11):3354-3359.

[3]Ackermann G, Löffler B, Adler D, Rodloff AC. In vitro activity of OPT-80 against Clostridium difficile. Antimicrob Agents Chemother. 2004 Jun;48(6):2280-2.