Telacebec

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Chemical Structure| 1334719-95-7 同义名 : Q203; IAP6
CAS号 : 1334719-95-7
货号 : A130837
分子式 : C29H28ClF3N4O2
纯度 : 99%+
分子量 : 557.01
MDL号 : MFCD28502122
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(32.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Imidazopyridine amide as inhibitor of Mycobacterium tuberculosis by targeting its respiratory cytochrome bc1 complex. Telacebec effectively suppresses the growth of both MDR and XDR Mycobacterium tuberculosis strains in culture broth, exhibiting potency in the low nanomolar range. Against the benchmark strain Mycobacterium tuberculosis H37Rv, Telacebec shows MIC50s of 2.7 nM in culture broth and 0.28 nM within macrophages[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

8.98mL

1.80mL

0.90mL

17.95mL

3.59mL

1.80mL
参考文献

[1]Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60.