Daidzein

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Chemical Structure| 486-66-8 同义名 : 黄豆苷元
CAS号 : 486-66-8
货号 : A129224
分子式 : C15H10O4
纯度 : 98%
分子量 : 254.24
MDL号 : -
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(196.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Daidzein, often found in nuts, fruits, soybean and soybean products, belongs to isoflavone phytoestrogens. Daidzein is considered chemoprotective and can be used as an alternative therapy for a wide range of hormonal disorders, including several cancer types[3]. In vitro, daidzein inhibited choriocarcinoma cell lines JAR and JEG-3 cells growth in a time- and dose-dependent (12.5 - 400 µM) manner and cell cycle was arrested at G1 phase through suppressing ERK pathway[4]. Daidzein significantly enhanced alkaline phosphatase (ALP) activity dose-dependently, with a maximal role at a dose of 10 μg/mL (P<0.05) in OCT1 cells. Daidzein (10 μg/mL) stimulated osteoblast proliferation and differentiation through stimulating the activation of the BMP-2/Smads pathway[5]. In vivo, C57BL/6J mice administered with western-style diet (WD) + genistein and WD + daidzein showed a robust decrease in body weight gain by 40% and 19%, respectively (p < 0.05), compared to WD-fed mice. Genistein reduced energy intake by 26%, and daidzein decreased energy intake by 8% (p < 0.05)[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL
参考文献

[1]Jia TL, Wang HZ, et al. Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Biochem Pharmacol. 2003 Mar 1;65(5):709-15.

[2]Sugimoto E, Yamaguchi M. Stimulatory effect of Daidzein in osteoblastic MC3T3-E1 cells. Biochem Pharmacol. 2000 Mar 1;59(5):471-5.

[3]Křížová L, Dadáková K, Kašparovská J, Kašparovský T. Isoflavones. Molecules. 2019 Mar 19;24(6):1076. doi: 10.3390/molecules24061076. PMID: 30893792; PMCID: PMC6470817.

[4]Zheng W, Sun R, Yang L, Zeng X, Xue Y, An R. Daidzein inhibits choriocarcinoma proliferation by arresting cell cycle at G1 phase through suppressing ERK pathway in vitro and in vivo. Oncol Rep. 2017 Oct;38(4):2518-2524. doi: 10.3892/or.2017.5928. Epub 2017 Aug 28. PMID: 28849226.

[5]Yu B, Tang DZ, Li SY, Wu Y, Chen M. Daidzein promotes proliferation and differentiation in osteoblastic OCT1 cells via activation of the BMP-2/Smads pathway. Pharmazie. 2017 Jan 10;72(1):35-40. doi: 10.1691/ph.2017.6502. PMID: 29441895.

[6]Luo T , Miranda-Garcia O , Sasaki G , Wang J , Shay NF . Genistein and daidzein decrease food intake and body weight gain in mice, and alter LXR signaling in vivo and in vitro. Food Funct. 2018 Dec 13;9(12):6257-6267. doi: 10.1039/c8fo01718b. PMID: 30402623.