Tinidazole
产品说明书
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同义名 : | CP 12,574; CP12574; Tricolam; Teofarma; Simplotan; Fasygin; Fasigyne; Fasigyn; Fasigin; Farmasierra; Bioshik |
| CAS号 : | 19387-91-8 | |
| 货号 : | A128250 | |
| 分子式 : | C8H13N3O4S | |
| 纯度 : | 97% | |
| 分子量 : | 247.27 | |
| MDL号 : | MFCD00057217 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(202.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 3 mg/mL(12.13 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa. Tinidazole is an effective treatment against anaerobic microorganisms based on its pharmacokinetic characteristics (Cmax 51 microg/ml, t1/2 12.5h) and its excellent in vitro activity. Its long half-life allows once a day regimens. Tinidazole was recently approved by the Food and Drug Administration (FDA) for the treatment of infections caused by Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia[3]. Since tinidazole has no activity against aerobic bacteria, it must be combined with other antibacterial agents in the treatment of mixed infections involving aerobic and anaerobic bacteria[4]. TNZ (Tinidazole) outperforms ABZ (albendazole) in the treatment of Giardia infections in children from developing countries[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02934048 | Therapeutic Duration ... 展开 >> Helicobacter Pylori Antimicrobial Susceptibility Test Eradication 收起 << | Phase 4 | Unknown | June 2017 | - |
| NCT03139253 | Antimicrobial Susceptibility T... 展开 >>esting Triple Therapy 收起 << | Phase 4 | Not yet recruiting | June 30, 2017 | - |
| NCT03124420 | Helicobacter Pylori Infection | Phase 4 | Completed | - | Taiwan ... 展开 >> Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan Taipei, Taiwan, 10449 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.04mL 0.81mL 0.40mL |
20.22mL 4.04mL 2.02mL |
40.44mL 8.09mL 4.04mL |
| 参考文献 |
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