EGFR-IN-7

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Chemical Structure| 2267329-76-8 同义名 : TQB3804
CAS号 : 2267329-76-8
货号 : A1275056
分子式 : C32H41BrN9O2P
纯度 : 99%
分子量 : 694.6
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(5.76 mM)，配合低频超声，水浴加热至45℃，并调节pH至5，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • mutant EGFR

    EGFRd746-750/T790M/C797S, IC50:0.26 nM

    EGFRL858R/T790M, IC50:0.19 nM
描述 EGFR-IN-7 is a highly potent, selective, and orally active inhibitor of EGFR kinase. It exhibits inhibitory activity against both EGFR (WT) and EGFR (mutant C797S/T790M/L858R), with IC50 values of 7.92 nM and 0.218 nM, respectively. EGFR-IN-7 is applicable for research pertaining to various cancers[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.20mL

1.44mL

0.72mL

14.40mL

2.88mL

1.44mL
参考文献

[1]Ling WY, et, al. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase. WO2019015655A1.