Carboxyamidotriazole Orotate

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Chemical Structure| 187739-60-2 同义名 : L-651582 Orotate; CAI Orotate
CAS号 : 187739-60-2
货号 : A1274889
分子式 : C22H16Cl3N7O6
纯度 : 98%
分子量 : 580.76
MDL号 : MFCD22572756
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(6.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Calcium Channel
描述 Carboxyamidotriazole Orotate, the orotate salt of Carboxyamidotriazole (CAI), is recognized for its ability to inhibit signal transduction. It acts as a cytostatic blocker of nonvoltage-operated calcium channels and pathways dependent on these channels, showcasing antitumor, anti-inflammatory, and antiangiogenic properties[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.61mL

1.72mL

0.86mL

17.22mL

3.44mL

1.72mL
参考文献

[1]Corrado C, et al. Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PLoS One. 2012;7(8):e42310.

[2]Hussain MM, et al. Phase II trial of carboxyamidotriazole in patients with relapsed epithelial ovarian cancer. J Clin Oncol. 2003 Dec 1;21(23):4356-63.