Amantadine-d15

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Chemical Structure| 33830-10-3 同义名 : 金刚烷-d15-1-胺 ;1-Aminoadamantane-d15; 1-Adamantanamine-d15
CAS号 : 33830-10-3
货号 : A1268273
分子式 : C10H17N
纯度 : 98% 98%atom%D
分子量 : 166.34
MDL号 : MFCD01317436
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Amantadine-d15 is a deuterium-labeled version of Amantadine, which enhances its utility in scientific research by allowing for better tracking of its pharmacokinetics and metabolism. Amantadine itself is an antiviral agent effective against influenza A viruses, functioning by blocking the M2 proton channel, thus inhibiting the release of viral RNA into the cytoplasm of infected cells. Additionally, Amantadine serves as an antiparkinsonian agent[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.01mL

1.20mL

0.60mL

30.06mL

6.01mL

3.01mL

60.12mL

12.02mL

6.01mL
参考文献

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.