FIIN-3

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Chemical Structure| 1637735-84-2 同义名 : -
CAS号 : 1637735-84-2
货号 : A126279
分子式 : C34H36Cl2N8O4
纯度 : 98%
分子量 : 691.61
MDL号 : MFCD28386554
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(13.01 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • FGFR2

    FGFR2, IC50:21 nM

  • FGFR3

    FGFR3, IC50:31.4 nM

  • FGFR4

    FGFR4, IC50:35.3 nM

  • FGFR1

    FGFR1, IC50:13.1 nM
描述 FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.45mL

0.29mL

0.14mL

7.23mL

1.45mL

0.72mL

14.46mL

2.89mL

1.45mL
参考文献

[1]Tan L, Wang J, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.