Tasimelteon
产品说明书
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同义名 : | BMS-214778; VEC-162; BMS214778, BMS-214778, BMS 214778, VEC162, VEC-162, VEC 162, Tasimelteon, Hetlioz |
| CAS号 : | 609799-22-6 | |
| 货号 : | A125322 | |
| 分子式 : | C15H19NO2 | |
| 纯度 : | 98% | |
| 分子量 : | 245.32 | |
| MDL号 : | MFCD09033789 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(142.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tasimelteon (BMS-214778) is a dual melatonin receptor agonist (DMRA) with 2.1-4.4 times greater affinity for the MT2 receptor than the MT1 receptor, making it a potential circadian regulator for Non-24-Hour Sleep-Wake Disorder (Non-24) [1][2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00548340 | Primary Insomnia | Phase 3 | Completed | - | - |
| NCT00548340 | - | Completed | - | - | |
| NCT01402076 | Healthy Volunteers | Phase 1 | Completed | - | United States, Missouri ... 展开 >> Bio-Kinetic Clinical Applications Springfield, Missouri, United States, 65802 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.08mL 0.82mL 0.41mL |
20.38mL 4.08mL 2.04mL |
40.76mL 8.15mL 4.08mL |
| 参考文献 |
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