Echinacoside

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Chemical Structure| 82854-37-3 同义名 : Kusaginin; trans-Verbascoside; trans-Acteoside; NSC 603831
CAS号 : 82854-37-3
货号 : A125304
分子式 : C35H46O20
纯度 : 99%+
分子量 : 786.73
MDL号 : MFCD00075695
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(63.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 35 mg/mL(44.49 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, effectively inhibits Wnt/β-catenin signaling. Echinacoside can dose-dependently reduce phosho-LRP6, total LRP6, phosho-Dvl2, active β-catenin, and total β-catenin protein expression level in MDA-MB-231 and MDA-MB-468 cells[3]. Echinacoside shows both anti-apoptotic and anti-inflammatory properties, characterized by a substantial inhibition of hepatocyte apoptosis and a significant reduction in the inflammatory markers[4]. Echinacoside (30 - 270 mg/kg body weight; p.o.; daily for 12 weeks) significantly reverses the increases of body weight, serum hydroxyproline (HOP) levels, and the decreases of uterus wet weight and bone mineral density (BMD) in in ovariectomized (OVX) rats[5]. Echinacoside could increase viability of rat pheochromocytoma PC12 cells injured by Aβ (β-amyloid protein) and suppress the increase in intracellular reactive oxygen species (ROS) triggered by Aβ[6]. Moreover, transient treatment with echinacoside inhibits cytochrome c release and caspase-3 activation caused by ensuing rotenone exposure via activating Trk-extracellular signal-regulated kinase (ERK) pathway in neuronal cells[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00065715 Common Cold Phase 3 Completed - United States, Wisconsin ... 展开 >> University of Wisconsin-Madison Department of Family Medicine Madison, Wisconsin, United States, 53706-1490 收起 <<
NCT03463018 Generalized Anxiety Disorder Phase 2 Recruiting May 2019 Georgia ... 展开 >> Simon Skechinashvili University Hospital Recruiting Tbilisi, Georgia Contact: Ramiaz Shengelia, PhD MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.36mL

1.27mL

0.64mL

12.71mL

2.54mL

1.27mL
参考文献

[1]Zhang D, Li H, Wang JB. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity. Int J Biol Macromol. 2015 Jan;72:243-53.

[2]Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013 Feb;124(4):571-80.

[3]Tang C, Gong L, Lvzi Xu, Qiu K, Zhang Z, Wan L. Echinacoside inhibits breast cancer cells by suppressing the Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2020;526(1):170-175

[4]Li X, Gou C, Yang H, Qiu J, Gu T, Wen T. Echinacoside ameliorates D-galactosamine plus lipopolysaccharide-induced acute liver injury in mice via inhibition of apoptosis and inflammation. Scand J Gastroenterol. 2014;49(8):993-1000

[5]Li F, Yang X, Yang Y, et al. Antiosteoporotic activity of echinacoside in ovariectomized rats. Phytomedicine. 2013;20(6):549-557

[6]Zhang D, Li H, Wang JB. Echinacoside inhibits amyloid fibrillization of HEWL and protects against Aβ-induced neurotoxicity. Int J Biol Macromol. 2015;72:243-253

[7]Zhu M, Lu C, Li W. Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone. J Neurochem. 2013;124(4):571-580