BioE-1115

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Chemical Structure| 1268863-35-9 同义名 : -
CAS号 : 1268863-35-9
货号 : A1251863
分子式 : C19H18FN3O2
纯度 : 99%+
分子量 : 339.36
MDL号 : MFCD31381032
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(176.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CK2

    CK2α, IC50:10 μM
描述 BioE-1115 is a highly potent and selective inhibitor of PAS kinase (PASK), with an IC50 of approximately 4 nM. Additionally, BioE-1115 exhibits potent inhibition of casein kinase 2α, with an IC50 of around 10 μM [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.47mL

5.89mL

2.95mL
参考文献

[1]Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8(1):242-55.