ML67-33

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Chemical Structure| 1443290-89-8 同义名 : -
CAS号 : 1443290-89-8
货号 : A1251848
分子式 : C18H17Cl2N5
纯度 : 99%
分子量 : 374.27
MDL号 : MFCD32215313
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(280.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 ML67-33 is a selective activator of temperature- and mechanosensitive K2P channels. ML67-33 rapidly and reversibly activates K2P2.1 (TREK-1), with EC50s of 36.3 μM and 9.7 μM in a cell-free system and HEK293 cells, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.72mL

5.34mL

2.67mL
参考文献

[1]Bagriantsev SN, et al. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16;8(8):1841-51.