LY3154207

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Chemical Structure| 1638667-79-4 同义名 : -
CAS号 : 1638667-79-4
货号 : A1250019
分子式 : C24H29Cl2NO3
纯度 : 99%+
分子量 : 450.4
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(233.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LY3154207 is a potent, orally bioavailable, and subtype-selective positive allosteric modulator (PAM) of the human dopamine D1 receptor, possessing minimal allosteric agonist activity (EC50=3 nM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.20mL

4.44mL

2.22mL
参考文献

[1]Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Po