SLC13A5-IN-1

产品说明书

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Chemical Structure| 2227548-95-8 同义名 : -
CAS号 : 2227548-95-8
货号 : A1250015
分子式 : C19H19Cl3N2O3S
纯度 : 99%+
分子量 : 461.79
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(25.99 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 SLC13A5-IN-1 is a specific inhibitor of the sodium-citrate co-transporter (SLC13A5). It completely inhibits the uptake of 14C-citrate in HepG2 cells, with an IC50 value of 0.022 μM. SLC13A5-IN-1 shows promise for the treatment of metabolic and/or cardiovascular diseases. This compound is derived from patent WO2018104220A1, specifically Compound I-5[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL
参考文献

[1]Joerg Kley, et al. Sulfonamides as inhibitors of the uptake of extracellular citrate. Patent WO2018104220A1