NCGC00229600

产品说明书

Print
Chemical Structure| 1338824-20-6 同义名 : -
CAS号 : 1338824-20-6
货号 : A1249999
分子式 : C30H29N3O3
纯度 : 99%+
分子量 : 479.57
MDL号 : MFCD25977097
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(104.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NCGC00229600 is characterized as an allosteric inverse agonist for the thyrotropin receptor (TSHR), effectively inhibiting the activation of TSHRs by both thyroid-stimulating hormone (TSH) and stimulating antibodies found in Graves' disease. This highlights its potential for therapeutic applications in treating conditions related to thyroid dysfunction[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.85mL

4.17mL

2.09mL
参考文献

[1]Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.