Yonkenafil

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Chemical Structure| 804518-63-6 同义名 : Tunodafil
CAS号 : 804518-63-6
货号 : A124931
分子式 : C24H33N5O4S
纯度 : 99%+
分子量 : 487.61
MDL号 : MFCD28975335
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(215.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, effectively reduces cerebral infarction, neurological deficits, edema, and neuronal damage in affected areas. It may enhance cognitive function through neurogenesis modulation and potentially treats Alzheimer's disease[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.21mL

10.25mL

2.05mL

1.03mL

20.51mL

4.10mL

2.05mL
参考文献

[1]Xuemei Chen, et al. Yonkenafil: a novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke. Exp Neurol. 2014 Nov;261:267-77.