Oroxin B

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Chemical Structure| 114482-86-9 同义名 : Hypocretin-2
CAS号 : 114482-86-9
货号 : A123867
分子式 : C27H30O15
纯度 : 99%+
分子量 : 594.52
MDL号 : MFCD22125002
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(176.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • PI3K
描述 Oroxin B, a natural product isolated and purified from the roots of Scutellaria baicalensis., can selectively induce tumor-suppressive ER stress and concurrently inhibit tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.41mL

1.68mL

0.84mL

16.82mL

3.36mL

1.68mL
参考文献

[1]Li DQ, Zhao J, et al. Discovery of xanthine oxidase inhibitors from a complex mixture using an online, restricted-access material coupled with column-switching liquid chromatography with a diode-array detection system. Anal Bioanal Chem. 2014 Mar;406(7):1975-84.

[2]Qiu J, Wang D, et al. Molecular modeling reveals the novel inhibition mechanism and binding mode of three natural compounds to staphylococcal α-hemolysin. PLoS One. 2013 Nov 27;8(11):e80197.