GW280264X

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Chemical Structure| 866924-39-2 同义名 : -
CAS号 : 866924-39-2
货号 : A1227356
分子式 : C28H41N5O6S
纯度 : 98%+
分子量 : 575.72
MDL号 : MFCD33023416
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(208.43 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 GW280264X is an inhibitor of ADAM10/17 with IC50s of 11.5 nM and 8.0 nM, respectively[1].At a concentration of 3 µM, acting for 48 hours, GW280264X inhibited GS-7 cell proliferation[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.68mL

1.74mL

0.87mL

17.37mL

3.47mL

1.74mL
参考文献

[1]Christian Hundhausen, et al. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood. 2003 Aug 15;102(4):1186-95.

[2]Fabian Wolpert, et al. A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells. Neuro Oncol. 2014 Mar;16(3):382-91.

[3]Daniela Sommer, et al. ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. Brain Behav Immun. 2019 Aug;80:129-145.