BAY1217389

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Chemical Structure| 1554458-53-5 同义名 : -
CAS号 : 1554458-53-5
货号 : A122330
分子式 : C27H24F5N5O3
纯度 : 98%
分子量 : 561.5
MDL号 : MFCD30502614
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(187 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Kinesin

    Mps1, IC50:0.63 nM
描述 BAY 1217389 inhibits Mps1 kinase activity with an IC50 value below 10 nM and demonstrates excellent selectivity. In cellular mechanistic assays, BAY 1217389 disrupts nocodazole-induced spindle assembly checkpoint (SAC) activity and triggers premature exit from mitosis, leading to multinuclearity and tumor cell death. Moreover, BAY 1217389 efficiently suppresses tumor cell proliferation in vitro[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.90mL

1.78mL

0.89mL

17.81mL

3.56mL

1.78mL
参考文献

[1]Wengner AM, et al. Novel Mps1 Kinase Inhibitors with Potent Antitumor Activity. Mol Cancer Ther. 2016 Apr;15(4):583-92.. . . .