Necroptosis-IN-3

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Chemical Structure| 547698-18-0 同义名 : -
CAS号 : 547698-18-0
货号 : A1217669
分子式 : C12H17NOS
纯度 : 98%+
分子量 : 223.33
MDL号 : MFCD03397171
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(470.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Necroptosis-IN-3 functions as a necroptosis inhibitor targeting TNF-α induced necroptosis [1]. Necroptosis-IN-3 additionally hinders 11β-HSD1 activity [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.48mL

0.90mL

0.45mL

22.39mL

4.48mL

2.24mL

44.78mL

8.96mL

4.48mL
参考文献

[1]Satoh T, et al. Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases. Biochim Biophys Acta. 1996 Jan 11;1273(1):21-30.

[2]Nigel Vicker, et al. Compound. Patent US20100120789A1.