APX-115 free base
产品说明书
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同义名 : | Ewha-18278 free base; Isuzinaxib free base; EWHA-18278; APX 115; Isuzinaxib |
| CAS号 : | 1270084-92-8 | |
| 货号 : | A1216684 | |
| 分子式 : | C17H17N3O | |
| 纯度 : | 99%+ | |
| 分子量 : | 279.34 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(894.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | APX-115 is a potent, orally active pan-Nox inhibitor with Ki values of 1.08 μM, 0.57 μM and 0.63 μM for Nox1, Nox2 and Nox4, respectively[1].At a concentration of 5 μM for 60 min, APX-115 almost completely inhibited the expression of pro-inflammatory and necrotic molecules in high glucose-induced mouse podocyte cell lines[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.58mL 0.72mL 0.36mL |
17.90mL 3.58mL 1.79mL |
35.80mL 7.16mL 3.58mL |
| 参考文献 |
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