Sigma-1 receptor antagonist 1

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Chemical Structure| 1639220-19-1 同义名 : -
CAS号 : 1639220-19-1
货号 : A1216661
分子式 : C19H23Cl2N3O
纯度 : 99%+
分子量 : 380.31
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(13.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Sigma-1 receptor antagonist 1 is a highly potent and selective antagonist for the sigma-1 receptor (σ1R), displaying strong affinity (Ki = 1.06 nM) for the σ1R receptor. It demonstrates antineuropathic pain efficacy, making it a promising candidate for neuropathic pain management[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.15mL

2.63mL

1.31mL

26.29mL

5.26mL

2.63mL
参考文献

[1]Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.