BMS 182874

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Chemical Structure| 153042-42-3 同义名 : -
CAS号 : 153042-42-3
货号 : A1211519
分子式 : C17H19N3O3S
纯度 : 99%+
分子量 : 345.42
MDL号 : MFCD00871737
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(347.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 BMS 182874 is an orally active, highly selective endothelin receptor (ETA receptor) antagonist with an IC50 value of 0.15μM and a Ki of 0.055 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.48mL

2.90mL

1.45mL

28.95mL

5.79mL

2.90mL
参考文献

[1]Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608.