PHPS1

产品说明书

Print
Chemical Structure| 314291-83-3 同义名 : Phenylhydrazonopyrazolone sulfonate 1; PTP Inhibitor V; Protein Tyrosine Phosphatase Inhibitor V
CAS号 : 314291-83-3
货号 : A1210891
分子式 : C21H15N5O6S
纯度 : 99%+
分子量 : 465.44
MDL号 : MFCD01079012
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(53.71 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 PHPS1 is a potent and selective SHP2 inhibitor with Ki value of 0.73μM[1]. PHPS1 at dose of 3mg/kg (i.p.) decreased the number of atherosclerotic plaques without significantly affecting body weight, serum glucose levels or lipid metabolism in high-cholesterol diet fed Ldlr−/− mice[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.21mL

10.74mL

2.15mL

1.07mL

21.49mL

4.30mL

2.15mL
参考文献

[1]Hellmuth K, Grosskopf S, Lum CT, Würtele M, Röder N, von Kries JP, Rosario M, Rademann J, Birchmeier W. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80. doi: 10.1073/pnas.0710468105. Epub 2008 May 14. PMID: 18480264; PMCID: PMC2438240.

[2]Chen J, Cao Z, Guan J. SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation. BMC Cardiovasc Disord. 2018 Apr 27;18(1):72. doi: 10.1186/s12872-018-0816-2. PMID: 29703160; PMCID: PMC5923012.