BMPO

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Chemical Structure| 387334-31-8 同义名 : BocMPO
CAS号 : 387334-31-8
货号 : A1210251
分子式 : C10H17NO3
纯度 : 99%+
分子量 : 199.25
MDL号 : MFCD32196548
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(526.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BMPO is a superior spin trap with excellent cell permeability and good chemical and spectroscopic properties. BMPO can be used to detect thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals[1].In CHO cells, 2.5 mM or 25 mM of BMPO had no significant effect on cell viability. However, at a concentration of 50 mM of BMPO, there was a significant increase in cell death. At 25 mM, BMPO significantly reduced colony formation by 30% in CHO cells and significantly reduced oxygen consumption in CHO cells. At a concentration of 50 mM, BMPO completely inhibited colony formation in 9L cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.02mL

1.00mL

0.50mL

25.09mL

5.02mL

2.51mL

50.19mL

10.04mL

5.02mL
参考文献

[1]H Zhao, et al. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic Biol Med

[2]Nadeem Khan, et al. Spin traps: in vitro toxicity and stability of radical adducts. Free Radic Biol Med. 2003 Jun 1;34(11):1473-81.