L-745870 3HCl

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Chemical Structure| 866021-03-6 同义名 : -
CAS号 : 866021-03-6
货号 : A1209538
分子式 : C18H22Cl4N4
纯度 : 99%+
分子量 : 436.21
MDL号 : MFCD01074795
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 L-745870 trihydrochloride, a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist, has a Ki of 0.43 nM. This compound demonstrates lower affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.46mL

2.29mL

1.15mL

22.92mL

4.58mL

2.29mL
参考文献

[1]Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.

[2]Patel S, et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47.

[3]Kulagowski JJ, et al. 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor. J Med Chem. 1996 May 10;39(10):1941-2.