Adaptaquin

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Chemical Structure| 385786-48-1 同义名 : -
CAS号 : 385786-48-1
货号 : A1209379
分子式 : C21H16ClN3O2
纯度 : 97%
分子量 : 377.82
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(277.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Adaptaquin is an inhibitor of HIF-PHD2 with an IC50 of 2 μM. It can inhibit lipid peroxidation and preserve mitochondrial function[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.26mL

13.23mL

2.65mL

1.32mL

26.47mL

5.29mL

2.65mL
参考文献

[1]Smirnova NA, et, al. Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation. Chem Biol. 2010 Apr 23;17(4):380-91.

[2]Neitemeier S, et, al. Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis. 2016 May 5;7(5):e2214.